2,3-Butanedione 2-Monoxime

CAS No. 57-71-6

2,3-Butanedione 2-Monoxime( BDM | Diacetyl Monoxime | NSC 660 | NSC 116103 )

Catalog No. M15109 CAS No. 57-71-6

Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    2,3-Butanedione 2-Monoxime
  • Note
    Research use only, not for human use.
  • Brief Description
    Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.
  • Description
    Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.
  • In Vitro
    Biacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea.Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum.Biacetyl monoxime (0-30 mM) induces SR Ca2+ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction.Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI.Biacetyl monoxime (0-50 mM) suppresses L-type Ca2+ current of single cardiac myocytes isolated from SHR and WKY rats.Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.
  • In Vivo
    Biacetyl monoxime (0-200 mg/kg; i.v.; once) shows hypotensive effect.Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions. Animal Model:Male SHR and age-matched WKY rat Dosage:5, 30, I00 and 200 mg/kg Administration:Intravenous administration, 1 mL/kg, once Result:Decreased arterial blood pressure for both strains, the SHR was significantly more responsive.Animal Model:Male mice (20 to 25 g) Dosage:51, 103 and 205 mg/kg in combination with intraperitoneal injection of 3.0 mg/kg Picrotoxin (HY-101391)Administration:Intraperitoneal injection, once Result:Showed dose-dependent anticonvulsant effect against Picrotoxin-induced convulsions.
  • Synonyms
    BDM | Diacetyl Monoxime | NSC 660 | NSC 116103
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57-71-6
  • Formula Weight
    101.11
  • Molecular Formula
    C4H7NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C/C(=N\O)/C(=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vyomesh Patel, et al. Y Res, 2002, 62(5), 1401-1409
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