
2,3-Butanedione 2-Monoxime
CAS No. 57-71-6
2,3-Butanedione 2-Monoxime( BDM | Diacetyl Monoxime | NSC 660 | NSC 116103 )
Catalog No. M15109 CAS No. 57-71-6
Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | 35 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product Name2,3-Butanedione 2-Monoxime
-
NoteResearch use only, not for human use.
-
Brief DescriptionPerifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.
-
DescriptionPerifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7μM, targets pleckstrin homology domain of Akt.
-
In VitroBiacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea.Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum.Biacetyl monoxime (0-30 mM) induces SR Ca2+ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction.Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI.Biacetyl monoxime (0-50 mM) suppresses L-type Ca2+ current of single cardiac myocytes isolated from SHR and WKY rats.Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.
-
In VivoBiacetyl monoxime (0-200 mg/kg; i.v.; once) shows hypotensive effect.Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions. Animal Model:Male SHR and age-matched WKY rat Dosage:5, 30, I00 and 200 mg/kg Administration:Intravenous administration, 1 mL/kg, once Result:Decreased arterial blood pressure for both strains, the SHR was significantly more responsive.Animal Model:Male mice (20 to 25 g) Dosage:51, 103 and 205 mg/kg in combination with intraperitoneal injection of 3.0 mg/kg Picrotoxin (HY-101391)Administration:Intraperitoneal injection, once Result:Showed dose-dependent anticonvulsant effect against Picrotoxin-induced convulsions.
-
SynonymsBDM | Diacetyl Monoxime | NSC 660 | NSC 116103
-
PathwayPI3K/Akt/mTOR signaling
-
TargetAkt
-
RecptorAkt
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number57-71-6
-
Formula Weight101.11
-
Molecular FormulaC4H7NO2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM
-
SMILESC/C(=N\O)/C(=O)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Vyomesh Patel, et al. Y Res, 2002, 62(5), 1401-1409
molnova catalog



related products
-
Lupeol
Lupeol is a pentacyclic triterpene that has anti-inflammatory and antioxidant activity.
-
Akt1Akt2-IN-17
A potent, selective dual Akt1 and Akt2 inhibitor with IC50 of 3.5 nM and 42 nM, respectively.
-
PF-04691502
PF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM.